| Feb 22, 2025 · 7:30 PM | FC Cincinnati | TQL Stadium | FT | 0–1 |
| Mar 1, 2025 · 7:30 PM | Nashville SC | Sports Illustrated Stadium | FT | 2–0 |
| Mar 8, 2025 · 7:30 PM | Atlanta United FC | Mercedes-Benz Stadium | FT | 0–0 |
| Mar 15, 2025 · 2:30 PM | Orlando City SC | Sports Illustrated Stadium | FT | 2–2 |
| Mar 22, 2025 · 7:30 PM | Toronto FC | Sports Illustrated Stadium | FT | 2–1 |
| Mar 29, 2025 · 2:30 PM | New England Revolution | Gillette Stadium | FT | 1–2 |
| Apr 5, 2025 · 7:30 PM | Chicago Fire FC | Sports Illustrated Stadium | FT | 2–1 |
| Apr 12, 2025 · 4:30 PM | Orlando City SC | Inter&Co Stadium | FT | 0–0 |
| Apr 19, 2025 · 7:30 PM | D.C. United | Sports Illustrated Stadium | FT | 1–2 |
| Apr 26, 2025 · 4:30 PM | CF Montréal | Sports Illustrated Stadium | FT | 1–0 |
| May 3, 2025 · 7:30 PM | Inter Miami CF | Chase Stadium | FT | 1–4 |
| May 10, 2025 · 7:30 PM | LA Galaxy | Sports Illustrated Stadium | FT | 7–0 |
| May 14, 2025 · 8:30 PM | Nashville SC | GEODIS Park | FT | 1–2 |
| May 17, 2025 · 4:30 PM | New York City FC | Citi Field | FT | 0–2 |
| May 24, 2025 · 7:30 PM | D.C. United | Audi Field | FT | 2–0 |
| May 28, 2025 · 7:30 PM | Charlotte FC | Sports Illustrated Stadium | FT | 4–2 |
| May 31, 2025 · 7:30 PM | Atlanta United FC | Sports Illustrated Stadium | FT | 2–0 |
| Jun 14, 2025 · 8:30 PM | Austin FC | Q2 Stadium | FT | 1–2 |
| Jun 25, 2025 · 7:30 PM | Toronto FC | BMO Field | FT | 1–1 |
| Jun 28, 2025 · 7:30 PM | Minnesota United FC | Sports Illustrated Stadium | FT | 2–2 |
| Jul 5, 2025 · 10:30 PM | San Jose Earthquakes | PayPal Park | FT | 1–1 |
| Jul 12, 2025 · 7:30 PM | Philadelphia Union | Subaru Park | FT | 0–2 |
| Jul 16, 2025 · 7:30 PM | New England Revolution | Sports Illustrated Stadium | FT | 5–3 |
| Jul 19, 2025 · 7:30 PM | Inter Miami CF | Sports Illustrated Stadium | FT | 1–5 |
| Jul 26, 2025 · 8:30 PM | Chicago Fire FC | Soldier Field | FT | 0–1 |
| Aug 10, 2025 · 6:00 PM | Real Salt Lake | Sports Illustrated Stadium | FT | 2–1 |
| Aug 16, 2025 · 7:30 PM | Philadelphia Union | Sports Illustrated Stadium | FT | 1–0 |
| Aug 24, 2025 · 7:00 PM | Charlotte FC | Bank of America Stadium | FT | 0–1 |
| Aug 30, 2025 · 7:30 PM | Columbus Crew | Sports Illustrated Stadium | FT | 0–0 |
| Sep 13, 2025 · 10:30 PM | Portland Timbers | Providence Park | FT | 1–2 |
| Sep 20, 2025 · 7:30 PM | CF Montréal | Stade Saputo | FT | 2–0 |
| Sep 27, 2025 · 7:30 PM | New York City FC | Sports Illustrated Stadium | FT | 2–3 |
| Oct 4, 2025 · 7:30 PM | FC Cincinnati | Sports Illustrated Stadium | FT | 0–1 |
| Oct 18, 2025 · 6:00 PM | Columbus Crew | ScottsMiracle-Gro Field | FT | 1–3 |
| Feb 21, 2026 · 7:30 PM | Orlando City SC | Inter&Co Stadium | FT | 2–1 |
| Feb 28, 2026 · 2:30 PM | New England Revolution | Sports Illustrated Stadium | FT | 1–0 |
| Mar 8, 2026 · 4:30 PM | CF Montréal | Sports Illustrated Stadium | FT | 0–3 |
| Mar 14, 2026 · 1:00 PM | Toronto FC | BMO Field | FT | 1–1 |
| Mar 21, 2026 · 7:30 PM | Charlotte FC | Bank of America Stadium | FT | 1–6 |
| Apr 4, 2026 · 7:30 PM | FC Cincinnati | Sports Illustrated Stadium | FT | 4–2 |
| Apr 11, 2026 · 7:30 PM | Inter Miami CF | Nu Stadium | FT | 2–2 |
| Apr 18, 2026 · 2:30 PM | CF Montréal | Stade Saputo | FT | 1–4 |
| Apr 22, 2026 · 7:30 PM | D.C. United | Sports Illustrated Stadium | FT | 4–4 |
| Apr 25, 2026 · 7:30 PM | FC Cincinnati | TQL Stadium | FT | 0–2 |
| May 2, 2026 · 7:30 PM | FC Dallas | Sports Illustrated Stadium | FT | 0–2 |
| May 9, 2026 · 2:30 PM | Chicago Fire FC | Soldier Field | FT | 3–1 |
| May 13, 2026 · 7:30 PM | Columbus Crew | Sports Illustrated Stadium | FT | 3–2 |
| May 16, 2026 · 7:30 PM | New York City FC | Sports Illustrated Stadium | FT | 1–1 |
| May 23, 2026 · 8:30 PM | Sporting Kansas City | Sporting Park | FT | 2–1 |
| Jul 22, 2026 · 7:30 PM | Philadelphia Union | Subaru Park | FT | 1–3 |
| Jul 25, 2026 · 6:30 PM | Charlotte FC | Sports Illustrated Stadium | FT | 0–2 |
| Aug 1, 2026 · 7:30 PM | Orlando City SC | Sports Illustrated Stadium | FT | 3–2 |
| Aug 15, 2026 · 7:30 PM | Atlanta United FC | Mercedes-Benz Stadium | FT | 1–2 |
| Aug 19, 2026 · 7:30 PM | Nashville SC | Sports Illustrated Stadium | FT | 0–1 |
| Aug 22, 2026 · 7:30 PM | Chicago Fire FC | Sports Illustrated Stadium | FT | 1–1 |
| Aug 29, 2026 · 7:30 PM | Philadelphia Union | Sports Illustrated Stadium | FT | 1–3 |
| Sep 5, 2026 · 8:30 PM | Seattle Sounders FC | Lumen Field | FT | 0–0 |
| Sep 9, 2026 · 10:30 PM | LAFC | BMO Stadium | FT | 0–2 |
| Sep 12, 2026 · 7:30 PM | Columbus Crew | ScottsMiracle-Gro Field | FT | 1–0 |
| Sep 18, 2026 · 7:30 PM | New York City FC | Yankee Stadium | FT | 1–0 |
| Sep 30, 2026 · 7:30 PM | St. Louis CITY SC | Sports Illustrated Stadium | FT | 0–3 |
| Oct 10, 2026 · 7:30 PM | San Diego FC | Sports Illustrated Stadium | FT | 4–1 |
| Oct 14, 2026 · 7:30 PM | D.C. United | Audi Field | FT | 1–2 |
| Oct 17, 2026 · 7:30 PM | Toronto FC | Sports Illustrated Stadium | FT | 0–2 |
| Oct 24, 2026 · 5:30 PM | Inter Miami CF | Sports Illustrated Stadium | FT | 2–0 |
| Oct 28, 2026 · 7:30 PM | New England Revolution | Gillette Stadium | FT | 2–3 |
| Nov 7, 2026 · 4:00 PM | Atlanta United FC | Sports Illustrated Stadium | 11/7 - 4:00 PM EST | — |